Tumorigenicity by monoenergetic neutron in B6C3F1 mice

Abstract

This study was undertaken to investigate the tumorigenesis of monoenergetic neutron in mice. Monoenergitic neutron (HIRRAC) of 0.18, 0.32, 0.6 and 1.0 MeV were generated and irradiated in 6-weeks old both sexes B6C3F1 mice at dose of 50 cGy (0.5 cGy/min). The groups were observed for 13 months after irradiation. There were no significant differences of tumor inductions among energies.In another experiment, 7-weeks old C3H male mice were irradiated with 12.5, 25, 50 and 100 cGy of monoenergitic neutron of 0.2 and 0.6 MeV. Two weeks after irradiation, the male mice were mated with virgin 9-weeks old C57BL female and the mice shown an increased incidence of sperm abnormalities, which led to embryonic lethalities. Furthermore, liver tumors in male mice in 25 and 50 cGy of 0.6 MeV were tendency increased in contrast to unirradiated group. [J Radiat Res 44:373 (2003)]