Abstract
Common polymorphism in the TP53 gene (encoding Arg72Pro in p53) was analyzed in radiation-associated post-Chernobyl and spontaneous series of adolescent and adult papillary thyroid cancer (PTC) in patients of Russia by real-time PCR allelic discrimination assay and direct sequencing. Reference data for sporadic PTC were available for German caucasians. The distributions of sequencing variants in both radiation-associated series, but not in spontaneous one differed significantly from the reference group. Radiation-associated groups harbored at least heterozygous 72Pro significantly more often, and homozygous 72Arg less often than the reference group. The radiation-associated and spontaneous adult groups statistically differed from each other for these indexes. Data imply the different distribution of allelic forms of the TP53 in PTCs of diverse ethiopathogenic groups. [J Radiat Res 44:395 (2003)]
