Effect of Atm Status of Donor on Survival Following Bone Marrow Transfer of C3H mice

Abstract

The total body irradiation of C3H/He mice with 1-3Gy produce myeloid leukemias as compared with non-irradiated controls that produce fewer than 1% of leukemia (Radiat. Res., 127: 146, 1991). The thymic lymphoma (TL) prone ATM-deficient 129 strain (Cell, 86: 159, 1996) was crossed back into C3H/He strain. Lethally irradiated wild type C3H/He mice to which Atm-deficient bone marrow cells were transplanted showed a considerably shortened life span either in total or in TL-free survivals. Posttransplantation irradiation of BMT mice with 3Gy of X-rays gave rise to a faster development of TL but no prevailing leukemia in contrast with the case of transfer of p53-/- or p53+/- bone marrow in which undifferentiated stem cell leukemia emerged (Leukemia Res., 26: 1085, 2002). Again, both median and mean survivals of mice transfused with Atm-/- bone marrow cells significantly diminished regardless of emergence of TL or leukemia. The significance of ATM function to support BMT recipient will be discussed. [J Radiat Res 44:399 (2003)]