Abstract
In co-culture with osteoblastic cell line MC3T3-E1 and mouse bone marrow cell, the number of osteoclasts with in carbon ion irradiation group were fewer than that of gamma ray group or non-irradiated group. The outlines of an osteoclast in the carbon line irradiation group were irregular and small of a size. On the other hand, osteoclasts in the gamma ray irradiation group were large and stained for TRAP activity. Carbon ion irradiation had a more marked effect on osteoclast suppressed their maturation to a greater extent than did gamma irradiation. These observations suggest that carbon ion irradiation induces differential modulation of osteoclasts growth factor expression.
