Mutagenic effect of exposure rate of X ray

Masatake YAMAUCHI; Reiko UCHIYAMA; Kumiko FUKUTSU; Takako HATADA; Hiromi SAITO; Yuji YAMADA

doi:10.11513/jrrsabst.2005.0.252.0

The 48th Annual Meeting of The Japan Radiation Research Society

Session ID : P-A-138

DOI https://doi.org/10.11513/jrrsabst.2005.0.252.0

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Host: The Japan Radiation Research Society

Co-host: Asian Association for Radiation Research

Radiation Biology - Radiation Effects (mutation, chromosome aberration)

Mutagenic effect of exposure rate of X ray

*Masatake YAMAUCHI, Reiko UCHIYAMA, Kumiko FUKUTSU, Takako HATADA, Hiromi SAITO, Yuji YAMADA

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Abstract

We have been investigating the molecular mechanism of biological effects caused by the low dose rate irradiation.We have focused on the mutagenic effects caused by various kind of irradiation at the low-dose rate by detecting the Hprt gene mutation that shows 6-thioguanine resistance using the mouse cultured cell line. Also the mutation spectrum in the 6-thioguanine resistant cells were analyzed by the PCR-based LOH analysis of the Hprt genome gene domain.In this session, the frequency of appearance and mutation spectrum in the Hprt deficient mutants obtained through the X-ray exposure at various dose rates will be presented.

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