The Administration Effect of Sodium Tungstate on ICR Mouse Before Gamma-ray Irradiation

Abstract

Tungstate was reported to have a radical scavenging activity. In the present study, the pre administration effect of sodium tungstate on gamma-ray irradiated mouse was examined. Two groups of ICR male mouse were orally administered sodium tungstate solution for seven consecutive days, and the control group received saline, before whole body exposure to gamma radiation (6-12Gy). After irradiation, the measurements of body and tissue weight and hematocrit value and the estimation of DNA damage in tissue and blood cell by the comet assay were conducted. The body weight of tungstate administered mice slightly decreased after irradiation as well as that of control mice, and almost similar degree of spleen weight decrease after irradiation were observed in tungstate administered mice and control ones.