Host: The Japan Radiation Research Society
Co-host: Asian Association for Radiation Research
The fetus is known to be radiosensitive. The increased radiosensitivity of the gonocites with fetal age was reported when pregnant mice were exposed to single doses of X rays. Fetuses are also very sensitive to environmental endocrine disruptors. In the present study, we examined the effects of multiple contamination of tritiated water and vinclozolin, an endocrine disruptors with antiandrogen activity, orally administered to pregnant mouse on the fetus. Pregnant mice were orally administered HTO and vinclozolin at the middle gestation, and tritium concentrations of urine of pregnant mouse, blood and tissues of fetus and placenta and fetul membrane were determined with time until 20 days after the administration. The accumulation doses and biological half lives of HTO in mother mouse and fetus were calculated. Antiandrogenic effects of vinclozolin were also examined.
