Abstract
Clinical treatment of high-dose radiation exposure depends on radiation dosage. It is very difficult to cure the victims exposed to more than 10 Gy even by high-level medicine currently available. Under the circumstances, we only expect the development of generative medicine against DNA damage. In the case of less than 10 Gy exposure, we can expect the curability that depends on the quality of medicine. We have to discuss how to improve the quality of radiation casualty medicine for less than 10 Gy exposure. The problem of medicine for high-dose exposure is that it rarely happens. However, we can learn many things from hematopoietic stem cell transplantation. In the case of total body irradiation, a total of 12 Gy divided irradiation and lethal doses of DNA-damaging agents are administered. It is very important to evaluate complication, particularly cardiac and pulmonary functions as well as organs that may be damaged by infection. It is therefore needed to pay attention to such problems to improve the outcome of acute radiation casualty medicine. We have to insist that prevention of diseases associated with life-style and treatment of infectious diseases are also important for radiation casualty medicine.
