Abstract
It is important to understand non-targeted effects by ionizing radiation. In the present study, we examined a possibility of the induction of genomic instability by bystander effects. We have already reported that the yield of micronuclei in bystander xrs5 cells, that are defective in the function of non-homologous end joining pathway, is higher than that in normal CHO cells, therefore we examined the delayed effect in offspring of irradiated and bystander xrs5 cells. The result showed that the yields of micronuclei in progeny cells of irradiated xrs5 cells were similar to those in control cells. On the other hand, higher yields of micronuclei were observed in some progeny cells of bystander xrs5 cells, that were co-cultured with irradiated xrs5 cells, compare to those in control cells. These results suggest that genomic instability is induced by bystander signals from irradiated cells in non-targeted cells.
