Microgravity and gene expression

Abstract

Several spaceflight data suggest that alteration of gravity value induces a change in expression of many genes in cells. For some genes their transcription is up-regulated, while for other genes down-regulated. Such changes in gene expression are presumably attributable to alteration of cytoskeleton conditions. I will review the published data which support the idea, and discuss what changes may be expected for radiation-induced DNA damages in space.