Host: The Japan Radiation Research Society
Recently, obesity, which is one of the main reasons for adult disease such as diabetes, hypertension, hyperlipemia and so on, has increased rapidly. It is thought that obesity is induced when precursor cells differentiate into adipocyte and the cells hypertrophied by accumulating fat. Therefore, many scientists are paying a special attention to mechanism of cell differentiation of preadipocyte. We discovered that marine microbe products inhibited cell differentiation of adipocyte recently. Surprisingly, some of products have dedifferentiation function of adipocyte.
It is well known that the cell-cycle arrest in G1/G0 phase triggers induction of the cell differentiation. In addition, there is a lot of evidence that radiation induce cell-cycle arrest. Low-dose radiation which is one of the environmental stress induces the cell cycle arrest. So, it is likely that that appropriate levels of radiation dose induce cell differentiation of adipocyte. Therefore, mechanistic study of stress response may contribute to obese prophylactic technical development. In this presentation I will present differentiation derivation by radiation and the depression mechanism.
