The participation of the energy metabolic system in radiation carcinogenesis process

Abstract

For many years, it was thought that genetic changes caused by radiation were only due to DNA damage derived from the incident free radical species produced at the time of exposure. However, it was discovered that the number of surviving cells exhibiting increased delayed genetic effects following ionizing radiation is greater than would be predicted if only the cells exposed at the time of radiation were involved. In other words, the genetic effects of ionizing radiation were found to be trans-generational. These phenomena have been called non-targeted or bystander effects of radiation, but the mechanisms governing these phenomena are not well understood. The aim of this symposium is focused to discuss what is the mediator of this trans-genetical effects and how metabolic oxidative stress produced by steady-state energy production system contribute to this phenomena.