The Japan Radiation Research Society Annual Meeting Abstracts
The 51st Annual Meeting of The Japan Radiation Research Society
Session ID : BO-1-3
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Radiation Response / Signal Transduction
Molecular mechanisms for radiosensitive apoptosis in mouse pre-T cells
*Yoshisada FUJIWARAQing-Li ZHAOTakashi KONDO
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CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract
We investigated the molecular mechanisms by which mouse pre-T ST4 and STH1a cells (gift of I. Radford) undergo the hyper-radiosensitive apoptosis. One pathway was the p53-driven upregulation of BH3-only Puma, Bim and Noxa, which activated Bax and Bak to release cytochrome c from mitochondria and activate the caspase-9—capsase-3/7 cascade. Another pathway relied on the caspase-2 activation via p53-mediated PPIDosome. Independent of the above pathway, caspase-2 was inactivated by VDVAD-CHO or caspase-2 siRNA. Rrather than IR-irresponsive caspase-8 in these cells, furthermore, active caspase-2 had a novel role for Bid cleavage to tBid, which plays a role in Cytc release for DNA damage-induced, p53-dependent apoptosis. Thus, the above two pathways are the molecular basis of hyper-radiosensitive apoptosis in ST4 and STH1a cells.
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© 2008 The Japan Radiation Research Society
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