Host: The Japan Radiation Research Society
Co-host: City of Kitakyushu, University of Occupational and Environmental Health, Japan
We previously reported increases of body weights, weights of fatty tissues and contents of lipids in the liver from B6C3F1 female mice continuously irradiated with low-dose-rate (LDR) gamma-ray at 21 mGy/ day (0.95 mGy/hr). Here, we show serial changes in body weights, weights of tissues, the number of blood cells, contents of lipids in the liver and serum, and serum levels of adipocytokines from B6C3F1 female mice continuously irradiated with medium-dose-rate (MDR) gamma-ray at 400 mGy/ day (18.5 mGy/hr) to compare with those from LDR-irradiated mice. Body weights, weights of the fatty tissues and spleen, the number of red blood cells, white blood cells and platelets, contents of serum lipids, and serum levels of leptin temporarily decreased in MDR-irradiated mice, compared with those of nonirradiated mice, while no significant change in contents of lipids in the liver were observed between the MDR-irradiated and nonirradiated mice. On the other hand, weights of the spleen, the number of red blood cells and platelets also decreased in LDR-irradiated mice than those of nonirradiated mice, although body weights, weights of the fatty tissues, contents of lipids in the liver and serum, and serum levels of leptin increased in the LDR-irradiated mice, compared with the nonirradiated mice. These results indicate that lipid metabolism of mice following continuous gamma-irradiation might be different between LDR and MDR irradiation. Results will be shown on body weights and lipid metabolism of mice continuously irradiated with gamma-rays at 40, 60, 80, 100, 170 and 330 mGy/ day. This study was performed under contract with the Aomori Prefectural Government, Japan.
