Analysis of p53 activity in mice after exposure by 3H beta-rays and 137Cs gamma-rays

Abstract

We have examined the elevation of T-cell receptor (TCR) variant fractions in splenic T lymphocytes by beta-rays from tritiated water (HTO) with 3 Gy by a single i.p. injection and 137Cs gamma-rays with 3 Gy at a low dose rate mimicking internal expose (simulation-irradiation). In Trp53+/+ mice, although the TCR variant fraction did not increased at all by 137Cs gamma-rays, that by 3H beta-rays increased 19 day after injection. In this study, We analyzed the p53 activity in T cells from mice after whole body exposure by 3H beta-rays and 137Cs gamma-rays with 3 Gy.