Host: The Japan Radiation Research Society
Co-host: City of Kitakyushu, University of Occupational and Environmental Health, Japan
UV radiation shows biological effects not only through direct photochemical reactions with biomolecules but also in indirect ways mediated by photosensitizing reactions, one of which induces oxidative stress through production of reactive oxygen species. It has been demonstrated that UV produces oxidative damage in DNA and causes structural abnormalities of constituent proteins through the oxidative stress in the tissues like lens and skin, which are exposed to the environmental UV. This workshop aims to evaluate the significance of the biological effects by the oxidative stress UV produces, in comparison with the direct effects by its photochemical reactions. We are focusing on the main components of the genome and the biological structure, DNA and protein, and discussing the influences for them of the oxidative stress as well as the UV photochemistry in terms of not only cells but also tissues such as skin, intestine, and lens.
