ＤＮＡ二重鎖切断の認識・修復の分子機構：最前線と今後の課題

松本 義久; 小林 純也

doi:10.11513/jrrsabst.2008.0.56.0

The 51st Annual Meeting of The Japan Radiation Research Society

Session ID : W4

DOI https://doi.org/10.11513/jrrsabst.2008.0.56.0

Conference information

Host: The Japan Radiation Research Society

Co-host: City of Kitakyushu, University of Occupational and Environmental Health, Japan

Recognition and Repair of DNA Double-Strand Breaks: Recent Advance and Remaining Problems

*Yoshihisa MATSUMOTO, *Junya KOBAYASHI

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Keywords: DNA double-strand break (DSB), radiation biology, recognition and repair

CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract

DNA double-strand break (DSB) is considered the most critical lesion among various types of radiation-induced DNA damages and most responsible for biological effects of ionizing radiation. Therefore, the elucidation of the molecular mechanism how DSBs are recognized and repaired and how bio-protective responses, such as checkpoints and apoptosis, are activated is one of the central problems in radiation biology. This workshop will introduce recent advances and discuss still unsolved or newly emerged problems, extensively focusing on DSBs.

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