Estimates of Cell Inactivation by a Track Structure model and Biophysical Model for Heavy-ion Beams

Abstract

In a treatment planning for carbon-ion radiotherapy, it is necessary to estimate the biological effect of the carbon-ion beam. The physical dose and the relative biological effectiveness (RBE) are calculated to predict the biological dose equivalent to photon beams in the patient body for optimal treatment planning. So far, we found that the Microdosimetric Kinetic Model (MKM) is very useful in explaining the survival curve of in-vitro cells for high-energetic ion beams. The amorphous track structure model is used in the MKM calculation instead of the microdosimetric stochastic energy deposition. We would like to discuss about using the biophysical model for the biological dose calculation carbon-ion threatment planning.