The expression of CD133 in glioblastoma u251 ρ0 cell line

Abstract

Glioblastoma is one of the most aggressive tumors in human malignancy. It generally shows resistance to radiotherapy. Recently, a novel concept of cancerous tissue has been proposed in several tumor models. A tumor contains a small fraction of ‘tumor initiating cells’, which could maintain proliferation and activate survival responses. In the latest study, it has been shown that stem cell marker CD133 was expressed in glioblastoma under hypoxic condition (Griguer E. et al, 2007). In the present study we investigated the expression of CD133 in mtDNA-deleted ρ0 glioblastoma cells.