Higher-order chromatin structure and DNA damage response

Abstract

Higher-order chromatin structure plays a pivotal role in the function and maintenance of the genome. Ionizing radiation-induced DNA double strand breaks cause detrimental effects on chromatin structure, which result in the activation of DNA damage response and repair. Damaged chromatin is recognized by ATM, and subsequent modification of histones and recruitment of DNA damage checkpoint factors are essential for executing such processes. In this workshop, three topics related to DNA damage response, histone modification, and DNA repair are presented, and a role of chromatin structure on radiation response will be discussed.