Putting forward a proposal for Radiation Equivalent Coefficient in Chemical Cancer Risk Asssessment -Example of DDT Liver cancer risk-

Abstract

People are exposed to numerous chemicals that may cause serious damage to health, like cancers, without knowing of their risks. However it is virtually impossible to estimate the risk of each chemicals substance by performing animal testing and alterative approaches should be discussed. Therefore, the purpose of this study is developing a novel framework of cancer risk assessment. The author proposes the application of in vitro transformation assay to the risk assessment. The framework consists of Physiologically based Pharmacokinetic model, transformation assay and conversion of chemicals toxicity to radiation. For the case of DDT, the slope factor was estimated to be 0.143 to 0.152which provide good agreement with the US EPA estimation. The framework could be utilized to other chemicals substances.