Abstract
[Introduction] There are reported that alpha-tocopherol monoglucoside (TMG) which is a water-soluble glycosylated derivate of vitamin E has radioprotection effect, but there are few report that the data about the blood cell which used an animal for definitely. Thus, we studied a radioprotection effect of TMG for the effects on blood cell after the radiation exposure in mice.
[Material and method] We used ICR male mice, and they were divided into five groups and treated as follows; 1.Control, 2.Sham control, 3.Radiation only, 4.Radiation+TMG and 5. TMG+Radiation. The animals were exposed to 2Gy whole body irradiation, and they were administered intra-peritoneal (i.p.) to mice 600mg per kg body weight. We studied on 30 days later from the irradiation day before and we collected blood and determination the blood count (erythrocytes, leucocytes, lymphocytes, monocytes, granulocytes, thrombocytes) with provided blood.
[Results] Recovery after the radiation of the number of leucocytes (the number of lymphocytes and monocytes) was earlier by the dose of TMG than the irradiation group. Furthermore, as for the TMG treated group, a conjugation was easy in comparison with control group.
[Conclusion] TMG has radioprotection effect, early metabolism in the body and action on the body as water-soluble TMG is effective in preventing a fatal effect by radiation, and it is thought with action by the free radical scavenging that is a radioprotection effect by the antioxidant effect. In addition, TMG shows a higher radioprotection effect because of glucose, and it is thought that is able to protect the damage of the blood forming tissue by radiation. TMG prevents a sudden change of the blood cell, and it is thought that is able to disturb an immunity fall. In this study, we accepted a radioprotection effect for the mice of TMG. TMG has radioprotection effect, early metabolism in the body as water-soluble vitamin E. Thus, we hope that TMG is used to safely radioprotection agents.
