Abstract
Ionizing irradiation induces various types of DNA damages including DNA double strand breaks. Such DNA damages activate the DNA damage response system including DNA repair and signal transduction to keep genomic integrity. Therefore, failure of DNA damage response system to exclude cells with inaccurately repaired DNA, such as point mutations and chromosome abnormalities, leads to human diseases like cancer, neurodegenerative diseases and progeria by the altered genetic information. Recent studies have revealed that reorganization of damaged chromatin, such as posttranslational modification and/or exchange of histones, plays an important role in the regulation of DNA damage response.,
In this symposium, we will introduce recent progresses in the field of DNA damage response. We would like to discuss the mechanism of inappropriate DNA damage response leading to human diseases.
