Abstract
How are the chemical changes on DNA by ionizing radiation reflected to biological responses? What is the difference of the changes between radiation qualities? Although we have already known the difference of biological response to the different radiation quality, there is no consensus view of the reason why the differences are. For example, 'clustered damage site', where more than two damages exist within a few helical turns, is believed to play an important role for the differences. However,its substance has hardly been discovered. It is quite necessary for investigating characteristics of the radiation-induced DNA damage to develop and utilize de novo techniques and analytical methods. Based on the background above, we will discuss the truth of radiation- induced DNA damage on the workshop together with a few lecturers investigating mathematical physical chemistry of ionization cross -section of DNA constituents, mathematical biology of DNA damage production by ionizing radiation, and radiation chemistry of time and space distribution of radicals produced by water radiolysis.
