Radiation response of mouse lens and human lens epithelial cells

Abstract

Cataracts are opacities of the transparent lens. Mounting epidemiological evidence has indicated that lens opacification results from radiation exposure at lower dose and/or dose rates than previously thought. However, the biological mechanism behind radiation cataractogenesis is not known. We thence set out to examine the radiation response of mouse lens and human lens epithelial cells, and here shall present its preliminary results.