Abstract
MicroRNAs (miRNAs) are small noncoding RNAs of about 19-22 nucleotides that regulate protein expression by posttranscriptional silencing. Recent investigations have suggested that miRNA play important roles in cellular processes, including differentiation, cell proliferation and cell death. In 2008, Lawrie et al. showed the correlation between the serum levels of miR-21and relapse-free survival in patients with diffuse large B-cell lymphoma, suggesting that miR-21 may be a potential diagnostic biomarker for the disease. The aim of this study is to identify radiation exposure specific miRNAs in mouse plasma. We analyzed the expression profiles of 4 Gy of gamma-irradiated mouse plasma using TaqMan Array MicroRNA Card (ABI). Several miRNAs were increased or decreased compared with control mouse plasma. The dose response and time course of these miRNAs will be shown.
