Abstract
There are many kinds of flavonoid (over than 7000) derived from plants. However, their functions are not fully understood. We previously performed screening of about 40 kinds of flavonoids to find novel radiosensitizers derived from plants. From the screening, we found Flavonoid A (tentative name) has the faint cytotoxicity and definitive radiosensitization action in cancer cells. The present study compared the effects of Flavonoid A on radiosensitivity in normal cells and cancer cells. We used human lung normal fibroblasts (HFL-III) and mouse normal fibroblasts (C3H/10T1/2), and human lung cancer cells (H1299) and mouse cancer cells (C3H/MCA Cline 15) derived from C3H/10T1/2. Colony formation assay showed that Flavonoid A sensitized radiosensitivity more effectively in cancer cells compared with normal cells. Flavonoid A is regarded as an efficacious radiosensitizer because of its faint cytotoxicity and preferential sensitization to cancer cells.
