Abstract
Bystander effect is known as the signal transmission through secreted factors or GAP junction. This reaction is thought to be an important response against stress in cellular population. We observed bystander effects induced by X-irradiation and UV-irradiation. Severe damage are not induced so frequently in bystander response, but non-lethal change such as gene mutation are significantly occurring. On the other hand, vitamin C (ascorbic acid) is well known as anti-oxidant, and we want to know the possibilities of the biological usefulness. In our study, the results suggest that ascorbic acid is effective for non-lethal damage including bystander responses. The mitochondrial function is one of the key target in the reactions after irradiation, therefore we want to know the mechanisms to suppress the bystander response by the treatment of ascorbic acid.
