Abstract
Purpose: In this study, we reviewed a radiation protection effect and immunological enhancement effect for Shunkokan which was quality of natural product.
Methods: Six week old male ICR mice were purchased from Japan SLC Inc. and kept under standard conditions (room temperature 22+/-3°, humidity 60%), and consistent feeding and drinking water . Mice were used for experiments after at least two weeks of Shunkokan administration and Shunkokan administration was continued until the end of the experiment . Measurement of peripheral blood cell counts in mice. We divided an experimental group into control group, Shunkokan treated group and 2Gy irradiation group and Shunkokan + 2Gy irradiation group in total four groups. We used an SOD activity detection kit as an antioxidation experiment and tested it. Statistical analysis was performed by a parametric ANOVA test among the groups to determine significant difference in blood cell counts for each group.
Result: The measurement of number of leukocytes revealed increase of leukocytes of a Shunkokan treated group in comparison with control group. In addition, a radiation protection effect was seen in Shunkokan+2Gy irradiation group after irradiation with lymphocyte counts. In the SOD-like active measurement, a rise was seen in a Shunkokan treated group.
Conclusions: The radioprotection effect can be expected of Shunkokan treated group. Mouse peripheral blood antioxidant activity was increased by Shunkokan , and a relationship between the suppressive effect on radiation-induced leukopenia and the antioxidant effect was suggested.
