Abstract
The tumor suppressor p53 has been implicated in many important cellular processes, including regulation of apoptotic cell death, in the cellular response to DNA damage. When cells encounter genotoxic stress, certain sensors for DNA lesions stabilize and activate p53. Notably, the phosphorylation at serine-46 (Ser46) of p53 is essential for commitment to promote apoptosis. Recently, we have identified that DYRK2 is responsible for Ser46 phosphorylation in response to DNA damage. However, little is known about the pro-apoptotic genes induced by Ser46 phosphorylation. To address this issue, we have carried out the microarray screening and the ChIP-sequencing assay. Through the combination of these analyses and subsequent validation, we have identified several strong candidates that are specifically induced by Ser46 phosphorylation. I would like to discuss our progress based on these findings.
