The Effects of Atmospheric Pressure Plasma Irradiation on Cultured Cells

Abstract

　Currently, 9.6 million people die from cancer worldwide each year. Therefore, there is a need to find effective cancer treatments. In this study, we investigate the application to cancer treatment by performing plasma irradiation experiments on cells. We generated plasma under atmospheric pressure and is equal to the temperature of the atmosphere, therefore it is possible to irradiate the living body. In this study, first, normal cells derived from mice are irradiated with atmospheric pressure plasma to investigate their effects on cell proliferation and apoptosis. Apoptosis is the death of cells characterized by the regular fragmentation of nuclear chromatin DNA and the fragmentation of the cell itself through the cascade of signals through the mediation of various functional proteins in the cell. In addition, the effects of atmospheric pressure plasma irradiation of human-derived cancer cells on cancer cells were investigated in terms of both proliferation ability and gene expression of inflammatory cytokines.