Inhibition of TNBC Breast Cancer Cell Proliferation and Mechanistic Study by Atmospheric Low Temperature Plasma

Abstract

　In Japan, breast cancer ranks fifth in cancer-related deaths among women, constituting about 10% of all cancer fatalities. Existing treatments, like surgery or chemotherapy, have significant side effects. Especially, Triple Negative Breast Cancer (TNBC) demonstrates a high recurrence rate within three years and a shorter post-relapse survival. Given these challenges and the expected rise in breast cancer incidences, this study focuses on TNBC, exploring the potential of Atmospheric Low Temperature Plasma (ALTP) as a treatment. Recently recognized for its safety and adaptability in medical applications, this research delves into ALTP's effects on cultured breast cancer cells, emphasizing both cell proliferation and the gene expression of inflammatory cytokines, caspase 3 and 9.