2024 Volume 32 Issue 2 Pages 424-429
Pulmonary arterial hypertension (PAH) is a severe respiratory disease caused mainly by stenosis of small pulmonary arteries. For cure the disease, we focused on active nitrogen species (RNS), which are produced during atmospheric low temperature plasma (ALTP) generation and have vasorelaxant effects, in order to investigate the suppression of PAH symptoms. This study aims to investigate the suppression of PAH symptoms by focusing on reactive nitrogen species (RNS), which occur during PAH and have vasorelaxant effects.
In this study, we focused on PAH caused by stenosis of small pulmonary arteries and aimed to suppress symptoms using ALTP. In this study, we evaluated the suppression of PAH by in vivo administration of ALTP-irradiated saline solution (PTS: plasma treated saline) to a rat model of PAH using electrocardiographic P-waves. Therefore, it was suggested that PTS administered with ALTP treatment suppressed the symptoms of PAH.
