Abstract
Pulmonary arterial hypertension (PAH) is a serious respiratory disease primarily caused by the narrowing of pulmonary arteries due to inflammation of the smooth muscle and endothelial cells.There is still no drastic treatment for PAH. Substances such as nitrite ions, which are expected to inhibit inflammation, are present in the active nitrogen species (RNS) contained in plasma-irradiated saline solution (PTS: plasma-treated saline solution), which is irradiated with atmospheric pressure low-temperature plasma (ALTP).
Therefore, this study aimed to develop a novel treatment for PAH by suppressing inflammation through PTS administration in model rats, focusing on active nitrogen species (RNS), which are produced during PAH and have vasodilatory effects, and investigated their effects on suppressing inflammation and treating PAH symptoms. The evaluation included body weight measurement, ECG analysis to measure the specific ECG waveform that appears at the onset of PAH, and expression analysis of genes involved in the inflammatory process, such as IL-6 and STAT3.
