Abstract
In recent years, dialyzers are used to be sterilized by using ethylene oxide(EO) or formaldehyde (HCHO). But some problems are still remained for long term dialysis patients.
Recently, sterilization methods using such as autoclave and y-rays are developed and the methods are begun to be adopted on various kinds of dialyzers.
In this report, we tried to characterize the differences of these dialyzers by sterilization methods. From clinical investigations, no differences are found on removal ratio of creatinine, blood urea nitrogen (BUN), uric acid and inorganic phosphate among the methods of sterilizations. In vitro experiments, clearance of creatinine, urea, vitamin B12, bromsulphalein (BSP), and methyguanidine are compared and no critical problems from clinical standpoints are found. Therefore, we consider that sterilization by autoclave and γ-rays are worthwhile to use for further clinical evaluation to remove the side effects because of EO or ECHO.
