Abstract
As an approach to the implantable artificial kidney, we deviced a unique intrabowel-filtrate infusion artificial kidney which endowing gromerular filtration to hemofilter and tubular reabsorption function to the intestine.
Tests were carried out in dogs with renal failure, in which the blood was passed through a hemofilter via a cervical external shunt and the filtrate injected into a cecal fistula to permit reabsorption from thecolon. The hemofilter used are polyacrylonitryl, polymethylmethacrylate, and polysulfon.
Furthermore, U-shaped polysulfon hemofilter was designed in order to implant in the intraperitoneal space.
As the result of tests, animals were maintained contnuously by this system and survived for 180 hours. It seems to indicate a step forward in the development of implantable artificial kidney.
