Significance of serum β-thromboglobulin measurement as a useful parameter of biocompativility evaluation of dialyzer.

Abstract

Evaluation method of dialyzer from the viewpoint of biocompatibility currently includes influence on blood corpuscles, activation of complement system, immunological reactions, and so on. As it is not totally systematized yet, there is still a need to find out new parameters. In present study, β-thrombogloburin (β-TG) was studied if it can be a tool of biocompatibility evaluation. Among various membranes tested, β-TG showed a significant elevation after single use of PAN and Cuprophane. As to the difference of binding of hollow fiber, spiral type showed marked elevation. β-TG was only detected in the filtrate of EVA. Thus, β-TG was confirmed as a useful and practical method for evaluation of biocompatibility of dialyzer.