Concentration of heparin, activated coagulation time and AT-III during cardio pulmonary bypass

Abstract

In cardiopulmonary bypass (CPB) and after bypass heparin concentration was estimated. The amount of heparin administered was 3.61mg/Kg and pr.otamine 3.48mg/Kg. During CPB heparinemia was maintained 0.88u/ml to 0.95u/ml. After bypass the concentration of heparin recovered with protamine within normal range. Owing to heparin concentration and ACT, no additional heparin was necessary at least for 2 hours in CPB. The activity of AT-III was descended about 50% of normal AT-III in CPB, but recovered to control level until 4 or 6 hours after CPB.