Experimental studies on jump graft with 1.3% Dialdehyde starch treated porcine aortic xenograft valve

Abstract

Hemodynamic and pathologic changes of 11 jump grafts which were grafted between canine's right ventricle and pulmonary artery with woven dacron conduit containing 1.3% Diaddehyde starch treated porcine aortic xenograft valve were examined. Soon after replacement, no valve failure were noted. Eight of 11 canines survived for 18 months on the average, but three were died of bacterial endcarditis. Hemodynamic values before sacrifice showed two slight pressure gradients and three pulmonary regurgitations. On gross findings of conduit grafts, intraluminal surface of woven dacron were completely smooth.
Thickening or sclerosing of valve were noted in 9 leaflets and thrombus in one leaflet.
No atrophy and tear were seen. On light microscopic findings, collagen and elastic fibers of valve were well preserved, and inflammatory cell infiltration was minute and focally at leaflets, Therefore, DAS treated porcine aortic xenograft valve and woven dacron conduit were considered satisfactory for the conduit graft.