HEMODYNAMIC EFFECTS OF A PROSTHETIC MYOCARDIUM IN ACUTE EXPERIMENTAL FAILURE
1981 Volume 10 Issue 2 Pages 528-531
Details
1981 Volume 10 Issue 2 Pages 528-531
A prosthetic myocardium (PM) is being developed as the treatment of akinetic or dyskinetic regions in the left ventricle. The PM was implanted to replace an excised experimentally induced infarct. Under external control the PM actively contracts and dilates approximating the action of myocardium. When inactive it can be stopped in it systole or diastole.
Sixteen implantations in mongrel dogs weighing 29-35kg were carried out. Afterload and heart rate were maintained constant, while the preload was varied in steps by means of a right heart bypass. Left ventricular function curves (LVFC) were measured. Then 25.0±1.7% of left ventricular mass was resected, a patch of Electrolour was sutured over the defect and the PM was implanted. LVFC measurements were repeated with the PM active and inactive. LVFC with the PM active was above and to the left of curves obtained with the PM inactive in every experiments.
The results showed the combination of the remaining left ventricle and implanted PM shifts LVFC toward normal.
