1981 Volume 10 Issue 2 Pages 550-554
There have been few reports of objective evaluation methods for artificial liver support due to unknown hepatic toxins and difficulties of producing reversible hepatic failure model.
It is considered that the plasma cross circulation (PCC) will be extended the evaluation method for artificial liver support observing the influence against donor's liver, because the PCC is the method to depend on the donor's liver for the antidotal and metabolic functions.
We tried to conduct the PCC for donor dogs and hepatic failure dogs using various kinds of adsorbents in order to evaluate the adsorbability of adsorbent for unknown hepatic failure substances.
Results showed high biochemical levels after the circulation until the next day, and then gradually decreasing to the normal values within 10days all most of non-treated group. However groups treated with charcoal, XAD-7 and complex system (charcoal+resin) were all normal on the forth day after PCC. Furthermore, same results were obtained by high performance liquid chromatogram of each plasma and histological findings.
Thus, prognosis of donor reveals the efficiency of artificial liver support used on PCC.
