Abstract
The effects of shear rate on the rate of platelet adhesion and albumin adsorption onto polymer surfaces under controlled plate-flow conditions were studied in vitro. The experiments were carried out using human platelet-rich plasma and fluoresceine-isothiocyanate labeled bovine serum albumin.
Albumin adsorption rates onto polyethylenetelephthalate (PET) films was not affected by the shear rate for a range of shear rate from 0 to 141 sec-1 On the other hand, platelet adhesion onto PET films (from 0 to 99 sec-1) and fluorinated ethylene-propylene copolymer (FEP) films (from 0 to 33 sec-1) was greatly affected by the shear rate. The shear rate also affected the morphologicol feature of the platelets adhered on PET films.
