Adhesion Control of Blood Cells by Synthetic Polymers Having Amino Groups

Abstract

Adhesion of rat lymphocytes on microphase separated surface of Polystyrene-Polyamine Comb-type copolymer was investigated. Adhesivity and shape change of lymphocytes can be suppressed by surface of SA copolymers coated with plasma protein. Also, separation of B cell and T cell can be achieved on albumin coated SA surfaces. Formation of microphase separated protein layer (with difference of amount and degree of conformational change) on SA surfaces was indicated by measurement of adsorbed amounts of albumin. We assume that this microphase separated protein layer may regulate redistribution of glycoproteins present at the plasmamenbrane, and may recognize the difference of B cell and T cell.