Abstract
Is it possible to accumulate anti-cancer drugs for target organs
without side effects of such drugs?
A new methodology of magnetic accumulation chemotherapy for cancer using magnetic liquid contained in O/W and W/O/W emulsions was studied for this purpose.
Magnetic liquids, such as dextran or oleic magnetite, are injectable intraveneously without any toxity and pathological change. We used these ferro-magnetic materials for the carrier of anti-cancer drugs.
The W/O/W emulsion was first reported by Matsumoto in 1976, but used paraffin which is toxic to animals. Our W/O/W emulsion was made by using vegetable oils, oleic and stearic acids, using a different method and surfactants from the original report.
The O/W emulsion was prepared_easily by high pressure homogenizer with HCO as a surf act ant.
Studying the rheological aspects of these emulsions under various conditions, successful results of accumulation were obtained, where the magnetic field was over 1200 Oe/cm and the flow velocity was below 12 cm/sec. Encouraged by these results, metyl -CCNU contained in O/W emulsion and adriacine contained in W/O/W emulsion were injected for the treatment of AH-81, hepatoma of rats, and the magnetic field was applied over the inoculated part of rats tumor for 30 minutes, Me-CCNU was not effective, but adriacine contained in W/O/W emulsion was effective, especially in magnetic therapy.
From these results, it may be concluded that this new methodology is very promising for the treatment of cancer if magnetic materials such as not storaging and not toxic are obtainable.
