Abstract
Mathematical model of the circulatory glucose and insulin dynamics has been made by combining the compartments which express major vessels, capillaries in the major organs such as brain, liver, gut, kidney, and periphery, and extravascular spaces. The depancreatized dog loaded with iv glucose was controlled with peripheral or portal insulin infusion by open- or closed-loop devices. After the input of initial conditions and time-sequence of insulin delivery rate, the model well simulated the experimental results of both glycemia and insulinemia over the experimental period. Dynamics of glucose and insulin kinetics in liver and periphery were also depicked clearly.
These data indicated that the model is useful to analyse the dinamic properties of glucose and insulin kinetics in specific organs.
