Abstract
The changes of thrombocytes and their aggregation activity were investigated during the dialysis with two different membrane dialyzers. Cuprophane hollow fiber (TE-10) and polymethylmethacrylate hollow fiber (B2-150) were compared. The platelet aggregation was accelerated during the hemodialysis. B2-150 produced significantly more thrombocytopenia and higher plasma level of β-thromboglobulin than TE-10. However, no significant difference was seen in the fall of arterial oxygen tension during the dialysis with the two different dialyzers. Oral administration of trapidil (300mg/day) reduced the extent of thrombocytopenia during the hemodialysis with B2-150, but not with TE-10.
The results suggest differences in biocompatibility between TE-10 and B2-150.
