Abstract
Jpn. J. Artif. Organs 11 (3), 786-793 (1982) XAD-4 resin has been evaluated for its biocompatibility and performance. Because of significant white blood cell and platelet depletion, plasma filtration system utilizing polyacrylonitrile membrane was employed for direct perfusion of the ultrafiltrate through the resin in this study. Hepatic ischemia was produced by two stage operation in adult mongrel dogs. End-to-side portacaval anastomosis was performed following ligation of the gastroduodenal artery and occluder around the common hepatic artery was closed without anesthesia from outside of the body 48 hours later. Eight dogs tolerated the procedure. Four of them were control group who were treated by fluid replacement and general supportive care. Four dogs were treated group who were subjected to the plasma filtration system for 6 hours beginning at 2 hours after occlusion of the artery. Average and the longest survival time was 13±1 and 16 hours for control group, while 18±4 and 29 hours for treated group. In treated group, GOT and GPT level did not show abrupt increase. Neither white blood cell nor platelet counts showed significant depletion in the treated group. Efficacy and improved blood compatibility of this system learned by this study is interpreted to imply that this is ready for clinical application.
