Abstract
24 hours veno- arterial bypass in dogs was underwent using silicone hollow fiber (SHMO) and polypropylene hollow fiber membrane oxygenator (PHMO) in order to evaluate gas exchange capacity and blood damage for both oxygenators, especially we measured the volume of transudate fluid through microporous membrane during ECMO using PHMO. Gas exchange capacity of SHMO was stable but one of PHMO decreased between 12 hours and 18 hours after bypass because of retention of transudate fluid. Platelet counts were preserved 84.7% of prebypass level at 24 hours after bypass in SHMO group and 51.3% in PHMO. Serum free hemoglobin concentration maintained less than 50mg/dl in both groups. In PHMO group, serum transudated through membrane since 8 to 13 hours after bypass and increased to 210ml/hr at the end of bypass. And then urine output decreased significantly. We had to transfuse blood and electrohte fluid. Therefor SHMO is the excelent oxygenator for long term ECMO with regard to maintaining homeostasis of living body.
