Abstract
Second filters for DFPP were evaluated in vitro using albumin and IgG solutions and human plasma separated with 1st filter. The effects of operating conditions, such as plasma flow rate at inlet, filtration flow rate and temperature, on separating performance of membranes were investigated. The results showed that the sieving coefficient of IgG was strongly affected by temperature. This was due to the facts that the amounts of oligomers and polymers of IgG changed with temperature and the thickness of resistant layer of IgG polymers was influenced by temperature. The performance of membranes in mixed solution was different from that in one component solution. Thus, an evaluation method for the performance of 2nd filters was proposed.
