Plasticizers released from the extracorporeal circulation devices have been suspected harmful

Abstract

For the attempt at preventation from the plasticizers leak, inner surfaces of the blood tubings were coated by thin layer of gelatin or urethane. Plasma levels of di-ethylhexyl phthalate (DEHP) were measured during the hemodialysis treatment using the 2 types of coated blood tubings. Increments of DEHP levels were significantly suppressed by both gelatin and urethane coating. Gelatin decreased especially the plasma DEHP levels by 60%. Our results indicated that both gelatin and urethane coating of the blood tubings were effective to prevent from the release of plasticizers.